The Indian tennis ace was beaten by Japan's Aiko Nakamura 3-6, 2-6 in the second round at the Australian Open.
Targetting her second consecutive singles title, top seed Sania Mirza faced stiff resistance from American Mallory Cecil before snatching a hard earned win in the first round of the ITF women's tournament in Vancouver.
The Indian ace beat Thailand's Suchanan Viratprasert in the women's singles quarter-finals to set up a meeting with top-seed Li Na of China at the Asian Games.
After just four days the Asian challenge is all but over at the Grand Slam of Asia/Pacific
Sania Mirza and Anabel Medina Garrigues beat Ekaterina Bychkova and Martina Muller 6-3, 6-4 in the second round.
Nadia Petrova claimed a routine 6-3, 6-1 victory over Japan's Aiko Nakamura to reach the second round of the Bali Classic on Tuesday.
The eighth seeded Indian teenager beat qualifier Vilmarie Castellvi of Puerto Rico to set up a meeting with local hope Aiko Nakamura at the Japan Open.
The third-seeded Australian, who missed several months after suffering a virus that upset her balance, was beaten 6-4, 6-2 at the Bali International.
Greece's Eleni Daniilidou caused the biggest upset on the opening day of the Amelia Island championship when she cruised to a 6-0 6-4 victory over French 10th seed Marion Bartoli on Monday.
The Indian ace, who lost to Japan's Aiko Nakamura at the Aus Open, has 453 ranking points.
China's Li Na scored an emphatic 6-2, 6-2 win over ninth seed Dinara Safina in the Australian Open third round.
The 18-year-old thrashed Aiko Nakamura of Japan 6-1, 6-4 in the second round of the Japan Open.
The world number one, who missed the Australian Open last year, posted a 6-2, 6-2 win against Japan's Aiko Nakamura.
